Umlando wentuthuko we-TCR - T Therapy Cell
Ngo-2002, iqembu likaRosenberg lalingowokuqala ukuthola ukuthi isimilo - Ukungena ngaphakathi kwama-lymphocytes (ama-tils) ahlukaniswe ne-melanoma kungabulala amaseli emithetho ngokukhethekile lapho kukhuliswa futhi kudluliselwe ku-vitro. Kodwa-ke, kwamanye amathumba, ama-tils ajwayele ukuthola futhi athathe isikhathi eside ukwandisa e-vitro. Iningi lazo lingamaseli we-T esibulalayo ahlukaniswe ngemuva kokunwetshwa, kanye ne-anti eqhubekayo - Kulesi simo, abantu bahlola ukuthi ngabe i-antigen eyaziwayo - i-TCCE gene ekhethekile ingangeniswa kuma-lymphocytes ajwayelekile we-lymphocytes (PBL) ekwelashweni, okuyi-TCR - T Therapy yeselula.
Enqubweni yokuthuthuka kwe-TCR - T Healogy, sekunesibopho sokuthola ama-4:
Isizukulwane sokuqala se-TCR - T sahlukaniswa namaseli e-T eneziguli ezinokwamukelwa okuqondile kwe-t cell subsets, anwetshwe nge-vitro bese edluliswa emuva ukuze athole ukwelashwa. Ngenxa yenombolo encane yama-clores we-t t kanye nokwehlukana okukhulu, kunzima ukukhiqiza izimboni.
Isizukulwane sesibili se-TCR - T ukuhlanganisa amaseli we-T ngqo ama-antigen angenhla, thola ukulandelana kwe-TCR Gene, bese uyidlulisela kumaseli we-peripheral t ezigulini. Le ndlela yenza ukuthuthukiswa kwezimboni ze-TCR - T kungenzeka.
Isizukulwane sesithathu se-TCR - T ukuthuthukisa izidakamizwa ze-TCR - T Ngokulungisa ubudlelwano be-TCR, okwenza kungcono ukwazi kangcono ama-antigns, bese udlulisela kumaseli we-Tuse.
Okwesine - Isizukulwane se-TCR - T kuyinto eqondile yokwelashwa kwamaseli okubhekiswe emcimbini we-tumor Neoantigens, ngokuphendula okuthuthuke kakhulu nasekufezeni.
Yini i-tcr - trapy yeselula
I-TCR - T CLER TRELAPY, iDemo cell receptor ye-T
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