I-Inscc ye-TCR - T

Imbali yophuhliso lwe-TCR - T

Ngo-2002, iqela likaRosenberg yayikukuqalisa ukufumana ukuba i-turus - i-lymphocytes efihlakeleyo (ii-tils) zodwa kwi-melanoma inokubulala ngokukodwa iiseli ze-phutro. Nangona kunjalo, kwezinye izitulo, imihlaba ihlala inzima ukufumana kwaye ithathe ixesha elide ukwandisa i-vitro. Uninzi lwazo ziiseli ze-T timall Kule meko, abantu bayaphononongwa ukuba ngaba i-Antign yaziwa ukuba i-antign ye-general ikwaziswe kwi-lymphocytes eqhelekileyo ye-lymphocyte (PBL) yonyango, engu-TCR - T.

Kwinkqubo yophuhliso ye-TCR - T Itekhnoloji ye-T, iitoti ezine zinamava:

Isizukulwana sokuqala se-TCR - I-t sasiyedwa kwiiseli ze-T Ngenxa yenani elincinci le-TALY Clones kunye nomehluko omkhulu omnye umntu, kunzima ukwenza imibutho.

Isizukulwana sesibini se-TCR - T kukuvala iiseli ze-T esamkelwe ngokukodwa kwe-tumor ye-antigen, fumana ukulandelelana kwe-TNCH, kwaye emva koko uyidlulisele kwiiseli ze-PER zezigulana. Le ndlela yenza ukuba uvuseleleke kwi-TCR - Inokwenzeka.

Isizukulwana sesithathu se-TCR - I-T kukuphucula iziyobisi ze-TCR - Ukwenzela ukuba kube lula ukuqaphela i-tuma i-turuens, kwaye emva koko igqibile kwiiseli ze-TURE.

Okwesine - I-TCRE ye-TRCR - T iluncedo oluthile lweseli olukhethekileyo lwe-turum neoadens, ngempendulo ephucukileyo yokhuseleko kunye nokhuseleko.

Ithini i-TCR - T I-TW IXESHA

I-TCR - I-T yeseli yeseli, i-T ye-T zeseli - Iiseli ze-T ze-T.

Ibanga le-IIT Ibakala le-ID Inqanaba leklinikhi Ibakala lezorhwebo

I-TCR - T