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Insight TCC - T
Nhoroondo Yekuvandudza yeTCR - T Cell Therapy
Muna 2002, timu yaRosenberg yaive yekutanga kuwana iyo tumor - Intiltrating lymphocytte (Tils) yakaiswa kubva kuMelanoma Inogona Kuuraya Tumor masero kana ikakwirisa uye inowedzerwa mu vitro. Nekudaro, mune mamwe ma tumors, til kazhinji kazhinji zvakaoma kuwana uye kutora nguva yakareba kuwedzera mu vitro. Vazhinji vacho vari maseru emasiyanisi eTesera, uye antti akagadzirirwa - bundu risina kusimba. Mune izvi mamiriro, vanhu vari kuongorora kana iyo Antigen inozivikanwa - chaiyo tCR Gene inogona kuunzwa muropa reropa lymphocyte (PBL) kurapwa, tcr - tcret kurapwa.
Mukusimudzira maitiro eTCR - Tekinoroji mina, zvina zvave zviripo:
Chizvarwa chekutanga cheTCR - T yakagoverwa kubva kuT masero evarwere vane tumor ant one kuzivikanwa kweT cell subsets, yakawedzera mu vitro uye wozoshandiswazve kurapwa. Nekuda kweiyo nhamba diki yeT cell maw nguwo uye misiyano yemunhu muhomwe, zvakaoma kuyiridzwa.
Chizvarwa chechipiri cheTCR - t ndeyekunyura ma cell zvakanyatso kuzivikanwa neiyo bundu riri pamusoro apa, wana iyo tcr geneiko kutevedzana, uye wobva waendesa kune masero emarwere evarwere. Iyi nzira inoita kuti iyo inyoronyoro yeTCR - t
Chizvarwa chechitatu cheTCR - t ndiko kuvandudza kugeza kweTCR - T nekutsiva kushamwaridzana kweTCR, vachiita kuti ive nyore kuziva bundu, uye wobva washandisai kumarwere t masero.
Chechina - General TCC - T is a Chaizvoizvo Serapy kurapa kunonamira Tumor neoantigers, ine zvakanyanya kuvandudzwa kwebundo rekupindura uye kuchengeteka.
Chii chinonzi tcr - t cell kurapa
TCR - T Cell Therapy, Short yeT Cell Receptor
