Insight tcr - t

Mbiri Yabwino Kwambiri TCR - T

Mu 2002, gulu la Rosensberg linali loyamba kuzindikira chotupacho - zilonda za lymphocytes Komabe, mu zotupa zina, ma tils nthawi zambiri amakhala ovuta kupeza ndikutenga nthawi yayitali kuti achuluke ku Vitro. Ambiri aiwo ndi ma cell osiyanasiyana atakula pambuyo pakukula, ndi anti - chotupa chimakhala chofooka. Pankhaniyi, anthu akufufuza ngati antigen - Genel Genel Itha kukhazikitsidwa mu zotumphukira, zomwe ndi tcr - ma cell mankhwala.

Pakukonzekera kwa TCR - T Technology, Amisamu anayi adziwa:

M'badwo woyamba wa TCR - T adatalikirana kuchokera ku ma cell a T omwe amadziwika kuti ndi chotupa chambiri cha ma cell a T Cellosets, akukulitsidwa mu vitro kenako ndikutumizanso kumbuyo kwa chithandizo. Chifukwa cha kuchuluka kwa maselo a T ndi kusiyana kwakukulu, ndizovuta kuti mufasunge.

M'badwo wachiwiri wa TCR - T ndikudulidwa maselo a T Njirayi imapangitsa kuti pakhale wofananira ku TCR - T MUNA.

M'badwo wachitatu wa TCR - T ndikuwongolera mankhwala a TCR - T ndikuyesa kuzindikira kwa tcr, ndikupangitsa kuti zizindikiridwe bwino ma antigens, kenako ndikuzichepetsa kwa maselo oleza mtima a T.

Wachinayi - Mkulu TCR - T ndi njira yothandiza kwambiri ya cell yomwe ikuyenda yotupa, kuyankha kotupa ndi chitetezo.

Kodi tcr - t cell mankhwala

TCR - Mankhwala a Tre cell, mwachidule kwa Cell receptor - Maselo Omangidwa T, amakhazikitsidwa ndi ma cell a arge, kuti azindikire ndi kuwachotsa chotupa ndikukwaniritsa chotupa.

Iit kalasi Ind Kalasi Yachipatala Kalasi ya malonda

Tcr - t