Esikwaziyo ngokuphepha, ukusebenza kahle kwemithi yokugoma i-MRNA phakathi kokuhlolisisa kwakamuva

Ezinsukwini ezimbalwa zokugcina, ukuphepha nokusebenza ngempumelelo kwe-Messenger RNA, noma i-MRNA, imigomo itholwe ngaphansi kokuhlolisiswa okukhulu.

NgoLwesibili, i-U.S. Ukudla kanye Nezidakamizwa Ukuphathwa kwamemezela amasu okunciphisa ukukhawulela ukufinyelela kwe-COVID yesikhathi esizayo - Ukudutshulwa okungu-19 - okubili kwawo okugoma uMnuna -- Kulabo abaneminyaka engama-65 nangaphezulu noma ngokuphezulu - izimo zobungozi. I-ejensi izodinga ezinye izilingo zesayensi zibambe izibhamu zamaqembu amancane.

Le nhlangano yaphinde yathumela izincwadi ziye kwi-PFAA ne-PFIZER ngenyanga edlule ibatshela ukuthi banwebe amalebula okuxwayisa kwi-Mrna Covid yabo - Imithi engu-19 yokugomela abantu abangatholwa yingozi yokuvuvukala kwenhliziyo njengomphumela wokuvuvukala kwenhliziyo njengomphumela wokuvuvukala kwenhliziyo njengomphumela wokuvuvukala kwenhliziyo njengomphumela wokuvuvukala kwenhliziyo njengomphumela wokuvuvukala kwenhliziyo njengomphumela wenhliziyo okungenzeka.

Ochwepheshe bezifo ezithathelwanayo batshele izindaba ze-ABC ukuthi uMnu kanye nemijovo ye-MRNA sebefundwe amashumishumi eminyaka, imigomo iphephile futhi iyasebenza, nokuthi isibhamu saba nesandla ekusindiseni izimpilo ngesikhathi sendawo -

"Nakhu umugqa ophansi: Imijovo ye-MRNA ye-AVID, ngokusho kwezilinganiso ezivela eYale School of Public Health, uSusiwe," uDkt. Peter Hotez, "uDkt. Peter Hotez," uDkt. Hotezz, uprofesa we-virology eBaylor Collect of Medicine eHouston, etshela izindaba ze-ABC.

"Ngakho-ke esikhundleni sabantu baseMelika abayizigidi eziyi-1,2 abalahlekelwe yimpilo yabo ngenxa yezwe, bekungaba yizigidi ezingama-4,4," wanezela. "Ngakho-ke, ngicabanga ukuthi ngeshwa ukuthi anti - izishoshovu zokugomela ziqondise imigomo yokugoma iMrna njengazo, kodwa ubuchwepheshe obuhle."

Yini iMrna?

IMarna yatholwa ngokuzimela ngamaqembu amabili ngo-1961 ahlanganisa nezazi zezinto eziphilayo zaseFrance nezeMelika.

UDkt Peter Chin - Hong, uprofesa wezokwelapha kanye nochwepheshe wezifo ezithathelwanayo e-University of California, eSan Francisco, waholela ekuthuthukisweni kweCOVID - Imithi engu-2020.

Ngenkathi imigomo eminingi isebenzisa igciwane elibuthakathaka noma elingenamuntu ukuvuselela impendulo yomzimba, imigomo ye-MRNA ifundise umzimba ukuthi ingakwenza kanjani amaprotheni angavuselela ukuphendula komzimba futhi alwe nokutheleleka.

"Indlela esebenza ngayo ukuthi ayingeni naseNuculeus [yeseli] "Kodwa okubaluleke kakhulu, kuyazibeka - izinsuku eziningi, ezinsukwini eziningi, futhi ziyafa."

Waqhubeka, "Ngakho-ke mrna uyahamba, kepha imikhiqizo eyinto ebaluleke kakhulu -- Amaprotheni nama-antibodies -- yingakho sithola isivikelo."

I-Chin - IHong ibuye yabheka enye ingxenye yemisebenzi engafanele eye yasakazwa, okusho ukuthi imigomo ye-MRNA ingaguqula iDNA e-nucleus.

"Amangqamuzana ethu awakwazi ukuguqula i-MRNA ibe yi-DNA ngoba i-MRNA ayifaki i-DNA, okuyi-nucleus," engeza.

Sazi kanjani ukuthi kuphephile?

I-Chin - IHong ithe phakathi okukhulu - ukukala izivivinyo zomtholampilo ze-COVID - U-2020, abantu abangaphezu kuka-70,000 babandakanyeka ePfizer -

Ngaphezu kwalokho, abantu abangu-37,000 babandakanyeka ekuvivinyweni kokwelashwa kwe-MonayAna ngokugomela kwalo kwe-RSV, i-chin - hong uthe.

Abaphenyi bathola leyo miphumela emibi -- kufaka phakathi umkhuhlane, ubuhlungu bengalo nokuvuvukala endaweni yokujova -- I-AVID - Umgomo we-MRNA wawunjengezomqondo wendabuko, ongabi -

Izifundo ezingeziwe Ngithole ukuthi ukuphepha kokuxhasa kwakuhambisana nokuphepha kubike ukugonywa okuyinhloko.

"Kukhona yonke le mininingwane esetshenziselwa ukulandela imibiko yabantu, hhayi kuleli lizwe kuphela, okuhlangenwe nakho kwabo kusetshenziswa imigomo, kepha nakwamanye amazwe, amanye amazwe amaningi," Chin - Hing asho. "Kube nezifundo eziningi kusukela ngo-2020 kukhombisa ukuthi akunamthelela ekuvumeni, unhlangothi, zonke izinto abantu abakhathazeke ngazo."

UHotez uthe awekho ubuchwepheshe bokugoma ephelele, kufaka phakathi ubuchwepheshe beMrna, kepha bunezinzuzo zalo njengokuthi bakwazi ukwakhelwa ngokushesha imigomo yokugoma ngokushesha, ibavumela ukuba bathunyelwe ngokushesha.

Angavumelani nesinqumo se-FDA sokunciphisa isikhathi esizayo esikhuthalweni esizayo - Ukugobhozwa kwemithi engu-19 ngoba i-COVID sekulungile - imiphumela yesikhathi esifana nesifo senhliziyo.

"Ngicabanga ukuthi kunabantu abadala abaningi abancane, noma labo abangaphansi kweminyaka engama-65, abakhathalela ngokwanele nge-covion ende noma yenhliziyo ephansi ukufuna ukukwazi ukuqondiswa kwe-MRNA," kusho yena.

Kuthiwani nge-myocarditis?

Imibuzo ishintshiwe lapho iMyCarditis, okuvuvukala kwemisipha yenhliziyo, kwenzeka ngemuva kokwakheka -

I-myocarditis ingadala i-arrhythmias, okungukuthi ukushaya kwenhliziyo okusheshayo noma okungajwayelekile. Kungadala futhi izicubu zenhliziyo ukuba zenze buthaka, kuholele e-Cardiomyopathy, okuthinta amandla enhliziyo yokupompa igazi ngempumelelo.

Amacala we-myocarditis ne-pericarditis -- Ukuvuvukala kwe-sac equkethe inhliziyo -- ubonwe akuvamile ngemuva kokugoma kwe-Covid, ngokusho kwe- Izikhungo zokulawulwa kwezifo kanye nokuvimbela izifo.

Lapho sebevele benzeke, bekuphakathi kwabesilisa abadala abadala, imvamisa phakathi kweminyaka eyi-18 no-29, kungakapheli izinsuku eziyisikhombisa ngemuva kokuthola umuthi wesibili wokugomela umuthi we-Mrna Covid, kusho i-ejensi.

I-FDA, ekubuzeni izinkampani zokugoma ukwandisa amalebula abo okuxwayisa, imininingwane yokuphepha entsha "-- Idatha kusuka kwesinye sezinhlelo zokubhekwa kwe-ejensi kanye ne Ukutadisha kushicilelwe ngo-Okthoba Lokho kwalandela abantu abathuthukisa iMyOCarditis exhumene nemithi yokugoma.

I-Chin - IHong ithe ingozi ye-myocarditis iphakeme kakhulu ngemuva kweCOVID - 19 uma iqhathaniswa ngemuva kokugoma, nokuthi le nkontileka yenkontileka uqobo iphakeme.

"Ingozi ye-Covil iphakeme kakhulu ngokujwayelekile. Uma uyibheka, amacala angama-22 kuye kwangama-31 ngesigidi [phakathi] neminyaka eyi-18 kuye kwangama-29 njengesibonelo," kusho yena. "Ngesikhathi lapho lezi zimisholo zisetshenziswa kaningi kulelo qembu, [Ingozi ye-MyOCarditis] ingu-1,500 ngesigidi. Ngakho-ke, ukhuluma cishe ngo-22 5,500 ngesigidi."

Qaphela: Iphrintiwe kabusha kusukaIzindaba ze-ABC 'Zouni Benadjaad zaba nomthelela kulo mbiko.