Kwiintsuku ezininzi ezidlulileyo, ukhuseleko kunye nokusebenza kakuhle kwe-messenger RNA, okanye i-MRNA, ugonyo luze luphantsi.
NgoLwesibini, uLawulo lweS.SE. zimbini zeziphi iindlela zokugonya -- Kwabo baneminyaka engama-65 nangaphezulu okanye ngeemeko eziphakamileyo. I-Arhente iya kufuna ezinye iimvavanyo zesayensi kwiGreenlight
I-Arhente iphinde yathumela iileta kuzo zombini imoddena kunye ne-pizer kwinyanga ephelileyo ibaxelela ukuba bandise iileyibhile zesilumkiso kwi-Mnumzana Covid - Iitofu ezili-19 zokuhlaselwa ngabantu abanokubakho.
Iingcali zezifo ezosulelayo zathi iindaba ze-ABC ukuba uMnumzana ugonyo ufundwe kangangesithuba seminyaka, izitofu zokugonya zikhuselekile kwaye zisebenza, kwaye i-shots yayinegalelo ekusindiseni ubomi ngexesha lokugcina ubomi ngexesha le-Covidna -
"Nantsi indawo esezantsi: ugonyo lwase-MRNA lokugcina i-covid, ngokoqikelelo ukusuka kwi-Yale School," uGqirha Hotez, unjingalwazi we-virolor kwiKholeji ye-Baylor kwiKholeji ye-Baylor, waxelela iindaba ze-ABC.
"Ke endaweni ye-1.2 yezigidi yaseMelika ephulukene nobomi babo ngenxa yeCovided, yayiya kuba yi-4.4 yezigidi," wongeza. "Ke ngoko, ndicinga ukuba ngelishwa le nto i-anti - iintshukumo zokugonya zithagethi zithagethi zithi, kodwa yitekhnoloji elungileyo."
Yintoni irna?
UMnuna wafunyanwa ngokuzimeleyo ngamaqela amabini ngo-1961 kubandakanya neengcali zebhayoloji zaseMelika.
UGqr Peter Chin - I-Hong, unjingalwazi wamayeza kunye nengcali yesifo kwiDyunivesithi yaseCalifornia, eSan Francisco, eyokuphucula umoya ophuhlisayo, ekugqibeleni ukhuphekile kwi-2020.
Ngelixa uninzi logonyo lusebenzisa intsholongwane ebuthathaka okanye engasebenziyo ukuba ivuselele impendulo yomzimba, ugonyo lwe-MRNA lufundise indlela yokwenza iiproteni ezinokwenza impendulo yomzimba yokuzikhusela kwaye zilwe nosulelo.
"Indlela esebenza ngayo kukuba ayingeni nokuba uye kwi-nucleus [yeseli]. Ingena ngaphandle kwe-cytoplasm, okanye into enamanzi ngaphandle kwe-nucleus, kwaye ikhuthaza i-nucleus, kwaye ikhuthaza i-nucleus," Chin - Hong ixelele iindaba ze-ABC. "Kodwa okona kubaluleke kakhulu, yona - intshabalalo ibalulekile, Ngezi ntsuku zininzi, kwaye iyafa."
Waqhubeka, "ke umnumzana uyamka, kodwa iimveliso ezibaluleke kakhulu, kodwa iiproteni kunye nee-antibodies -"
I-Chin - I-HOG ikwajongana nelinye iqhekeza lezinto ezigwenxa ezisasazwayo, elibonisa ukuba ugonyo logonyo lwe-MRNA lunokutshintsha i-DNA kwi-nucleus.
"Iiseli zethu azinakuguqula uMnu ukuya kwi-DNA kuba uMelna akangeni kwiDNA, oko kukwi-nucleus," wongeze.
Sazi njani ukuba ikhuselekile?
I-Chin - I-Hong yathi ngexesha lokuvavanywa kweeKlinikhi ezinkulu zeCovids -
Ukongeza, abantu abangama-37,000 babebandakanyeka kuvavanyo lweklinikhi yeKlinikhi ye-RV, i-chin - i-hong yatsho.
Abaphandi bafumanise ukuba iziphumo ebezingalindelekanga -- kubandakanya umkhuhlane, iintlungu ezingalweni kunye nokudumba kwindawo yenaliti -- Kwi-Covidd - 19 Ugonyo lwe-Mnunna lwalunjengezitolo zemveli, ezingezizo - kwaye zazikufutshane - amazinga enkonzo yexesha elininzi elingaphezulu kwe-90%.
Izifundo ezongezelelweyo Ufumanise ukuba ukhuseleko lokunyusa kwakungqinelana nokhuseleko olunikezwe ukugonya.
"Kukho zonke ezo datha ezisetyenziselwa ukulandela iingxelo zabantu, kungekuphela kweli lizwe, amava abo asebenzisa izitofu, kodwa nakwamanye amazwe, amanye amazwe amaninzi," utshilo uChin - "Kukho izifundo ezininzi ukususela ngo-2020 ebonisa ukuba akukho mpembelelo ekuchumeni, ukubetha, zonke izinto ezikhathazekileyo ngabantu."
UHotez uthe akukho tekhnoloji yokugonya igqibelele, kubandakanya iTekhnoloji ye-MRNA, kodwa ineengenelo zayo njengokukwazi ukuba izelwe izitofu zokugonya ngokwesiko, ezivumela ukuba zithunyelwe ngokukhawuleza.
Uyavumelana nesigqibo se-FDA sokunciphisa umda kwi-Covid yexesha elizayo - I-19Cine ye-19Coine ye-19 ngenxa yokuba i-cofuid ide ibekho - Iziphumo zegama ezinjengee-coyidiovascular.
"Ndicinga ukuba zininzi abantu abadala abadala, okanye abangaphantsi kweminyaka engama-65, abachaphazelekayo ngokwaneleyo malunga ne-codidde okanye isifo sentliziyo esikhawulezayo ukuba bafune ukufumana i-MRNACINE," utshilo.
Kuthekani nge-myocarditis?
Imibuzo ijikeleze indlela myocarditis, ekuvusweni kwengqumbo yentliziyo, kwenzeka emva kokuba uCodd - Ugonyo lwe-19.
I-Myocardis inokubangela i-celahythmias, ekhawulezileyo okanye engaqhelekanga. Inokubangela nakubangela umsipha wentliziyo ukuba buthathaka, okukhokelela kwi-CardioMyopathy, echaphazela amandla entliziyo yokuposa igazi ngokufanelekileyo.
Amatyala e-Myocachitis kunye ne-pericarditis -- Ukuvuvukala kwe-SAC equlethe intliziyo -- iqatshelwe kunqabile ukugonyelwa inkazana, ngokutsho kwe Amaziko okulawula izifo kunye nokuthintela.
Xa sele bekho, ibiphakathi kwamadoda amakhulu akhulileyo, ephakathi kweminyaka eli-18 neli-29, kwiintsuku ezisixhenxe emva kokufumana idosi yesibini yogonyo, iarhente ithi.
I-FDA, ekubuzeni iinkampani zokugonya ukuba zandise iilebheli zazo zesilumkiso, ezicatshuliweyo "ulwazi olutsha lokhuseleko" -- Idatha evela kwenye yeenkqubo ze-Arhente yokhuseleko kunye ne Ukufundwa okupapashwe ngo-Okthobha Oko kwalandela abantu abaphuhlise i-myocardis enxulunyaniswa nezitofu zokugonya.
I-Chin - IHong yathi umngcipheko we-Myocardis uphakame kakhulu emva kokuba uCodd - 19 Uthelekiswa nokugonywa, kwaye loo ntshukumo yemvumelwano iphezulu.
"Umngcipheko we-covivid uphezulu kakhulu. Ukuba uyayijonga, ama-22 ukuya kwangama-22 kwisigidi sezigidi ezili-18 ukuya kwi-18 ukuya kwi-18 ukuya kwi-18 ukuya kwi-29 ubudala ubudala. Ngexesha apho ezi ndlela zigonyo zisetyenziswa rhoqo kweli qela, [i-myocardis ingozi] yi-1,500 yezigidi.
QAPHELA:Iindaba ze-ABC
IXESHA LOKUQALA: 2025 - 05 - 29 17 17:19:08
