Yini i-lentivirus

I-Lentivirus ingekalesi sigaba segciwane esibizwa nge-retrovirus enohlobo lwe-rna kunokuba i-DNA. Ukukhiqiza imikhiqizo ye-gene esebenzayo, leli gciwane liqukethe futhi i-enzyme reverse transcrasese, ekhiqiza i-CDNA kwisifanekiso se-RNA. Lapho iseli e-endocytoses i-lentivirus yizinhlayiyana, i-rna ikhishwa futhi ibuye kabusha i-transcriptase ikhiqiza i-CDNA. I-DNA ihamba iye kwi-nucleus, lapho ihlangana khona ne-genome ye-host.

I-Lentivirus iyakwazi ukuthelelelela ukuhlukanisa kanye namaseli e-posttotic, kususelwa ku-human immunodeficielian virus futhi unekhono elingu-8 - kb. Ngoba i-DNA ihlangana kwi-genome, ukulethwa kwe-lentivirus kuholela ende - inkulumo yesikhathi. Ama-lentiviruses ama-retrovireses abumbana afaka i-gag ku-orf eyodwa ne-pro - epul kwenye. Ukukhiqizwa kwe-gag - pro - polyprotein proyprotein kudinga i-ribosomal framsift ekugcineni kwe-gag. Izinhlayiya ze-lentivirus zihlangana ku-membrane yeseli futhi zine-cores ehlukile ye-condes, futhi i-genome yegciwane icishe ibe ngu-9.3 KB ubude. Ama-lentivirises afaka i-HIV - 1 ne-HIV - 2, i-SIV, i-arthrine arthritis ebentu rus virus, negciwane le-visna.

Ukulawulwa kwekhwalithi yobuchwepheshe be-lentivirus 

Izinto zokuhlola ezisezingeni eliphakeme zokulawula ze-Lentiviral Vector kufaka phakathi ukubukeka, ukukhonjwa, ukutholwa kwe-virus, ubumsulwa, umsebenzi we-assuray wemvelo, izinto eziphikisayo zengozi, ama-ejensi anobungozi obude, ukungcola, njll.