I-NK yeeseli zokwandiswa kwekhithi
I-NK yeeseli zokwandiswa kwekhithi
✔ Iinjineli ze-N562 iiseli ze-K562 ye-Feeds (il - 21+ 40+ 40)
Ngaphambi - Ikhutshwe, iCytokiine - Ukuphuculwa kwe-NK.
I-Serum - I-Serum ye-NK yokwandiswa kweKit
I-GMP - Imithombo yeendaba ehambelana nekliniki - Ukuveliswa kwamanqanaba.
Ukuphakama - Iiseli zoCembira NK (> Ii-90% ze-CD56 +)
Iqinisekisiwe zombini kwimithombo yegazi ye-PBMC kunye ne-cord.
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Sebenzisa ukusetyenziswa:
Yenzelwe iseli ye-NK kunye nemoto - i-NK yeseli kwigazi le-periphelt (PBMC) kunye negazi lentambo.Process development stage: Accelerates early-stage cell therapy development while reducing time and cost, facilitating faster advancement of CAR-NK/NK cell therapy products.
Inkcazo yokusebenza
Ipharamitha yokusebenza Ukucaciswa I-NK ucoceko lweseli (%) > Iipesenti ezingama-90 I-CD3 + Iseli entsalela ye-CD3 (%) <1% I-NK ye-NK > I-5,000 - Songa Ukusebenza kweseli (%) > Iipesenti ezingama-80 Isishwankathelo sedatha:
Njengoko iiseli ze-NK zikhula njenge-allogenec, off - I-I - I-Shelf Therapeutics, iimfuno ezingqongqo zibekwe kuwo omabini amandla kunye nobunyulu. Inkqubo yolwandiso lwe-Blue ® I-NK yeseli yenza:
• Ukwanda komeleleyo kunye nokubuyiselwa - iphumelela> I-10,000 - Songa i-SLIFISI YOKUZIPHATHA NGEXESHA LEMIHLA
• I-Donor - kwi - Ukungasebenzi - Gcina amaxabiso olwandiso abazinzileyo kwabo banikele
• Ucoceko oluphezulu lwe-NK (Iphaneli yasekhohlo)Ngokukodwa, i-14 - Imini eyandisiweyo ye-NK igcina umsebenzi onamandla we-tummicridal nasemva kokuthungwa kunye nokutsala (iphaneli yasekunene).
T Ukucoceka kweselula (ngaphambi - vs iposi - Ukukhetha)
I-TW yokwandiswa kweSeli:
I-TEPE I-T Spegeation Readnt Readnt kwaye yandiswa ngaphakathi I-Serum - I-TWIAL ye-TW I-SALLAN DIOD,
Ukubonisa:> I-100 - Ukusondela (Ngemini 10 - 14),Ukusebenza okungaguqukiyo> 90%
Igcinwe i-T - Umsebenzi weseli (CD4 + / CD8 + umlinganiso wolondolozo)
Ukwanda kweeseli kunye nokusebenza
I-CD19 yokuTshintshela kweCd19 isebenza kakuhle:
Imodyuli yokutsalwa kwemoto, xa idityaniswa ne-chiral yorinteri ye-ntsholongwane B (Viral E - I-hancer b),
Ubonisa:> Iiseli ezingama-60% ye-TAC + TCS nge-Cytometry ye-2 - Ukuphuculwa kwesi-3 kwi-Lentiviser
Ukusebenza kweselfowuni
| Ipharamitha yokusebenza | Ukucaciswa |
| I-NK ucoceko lweseli (%) | > Iipesenti ezingama-90 |
| I-CD3 + Iseli entsalela ye-CD3 (%) | <1% |
| I-NK ye-NK | > I-5,000 - Songa |
| Ukusebenza kweseli (%) | > Iipesenti ezingama-80 |
Ulwazi lokuhambisa
Sinikezela ngothutho oluhlaziyiweyo kuyo yonke imiyalelo. Ngokwesiqhelo, iodolo yakho iya kufika ngaphakathi kwe-5 - Iintsuku ezisi-7 zeshishini eUnited States kwaye kwiintsuku ezili-10 zomsebenzi wamazinye amazwe. Nangona kunjalo, nceda uqaphele ukuba ukuhanjiswa kweendawo ezisemaphandleni kunokuthatha ixesha elide.
Ixesha lokuhambisa: Ii-odolo zihlala zisetyenzwa ngaphakathi 1 - iintsuku ezintathu zomsebenzi. Nje ukuba i-odolo yakho ithunyelwe, uyakufumana i-imeyile yokuqinisekisa ngolwazi lokulandela umkhondo.
Ulwazi olubalulekileyo
Ukuqhubekeka kocwangco: Emva kokuba i-odolo ihlawulwe, i-Warehouse yethu idinga ixesha lokuqhuba iodolo yakho. Uya kufumana isaziso emva kokuba i-odolo yakho ithunyelwe.
Amaxesha okuhambisa: Kwiimeko ezininzi, iphakheji iya kusiwa ngexesha eliqikelelweyo lokufika. Nangona kunjalo, umhla wokwenyani unokuchaphazeleka ngamalungiselelo eenqwelomoya, iimeko zemozulu, kunye nezinye izinto zangaphandle. Ixesha lokuhanjiswa kwexesha liya kuba ngaphezulu kwesiqhelo semiyalelo ebandakanya ukhuseleko okanye izinto ezenziwe ngokwezifiso. Nceda ujonge ulwazi lokulandelela ngowona mhla uchanekileyo wokuhanjiswa.
Imicimbi yokuhambisa: Ukuba ufumanisa ukuba iphakheji yakho ayihanjiswanga ngexesha elimiselweyo; Ulwazi lokulandela umkhondo lubonisa ukuba iphakheji ihanjisiwe kodwa awukayifumani; Okanye iphakheji yakho ibandakanya izinto ezilahlekileyo okanye ezingachanekanga okanye eminye imiba yempahla, nceda uqhagamshelane nenkonzo yethu yabathengi kwiintsuku ezisi-7 zomhla wokuhlawula ukuze sikwazi ukujongana nale micimbi ngokukhawuleza.
Ukulandelela umkhondo
Nje ukuba i-odolo yakho ithunyelwe, uyakufumana i-imeyile ngenombolo yokulandela umkhondo kunye nekhonkco lokulandelela ukuthunyelwa kwakho.
Unokulandelela i-odolo yakho ngqo kwiwebhusayithi yethu ngokungena kwiakhawunti yakho kwaye ujonge imbali yakho ye-oda.
Izithintelo zokuhambisa
Nceda ugcwalise idilesi yesitrato ngokweenkcukacha, hayi ibhokisi ye-PO okanye idilesi yomkhosi (AP). Ngaphandle koko, kuya kufuneka sisebenzise i-EMS yokuhanjiswa (ihamba kancinci kunabanye, ukuthatha malunga 1 - iiyure ezi-2 okanye ixesha elide).
Imisebenzi yesiko kunye nomgaqo-nkqubo werhafu
Nceda uqaphele ukuba nayiphi na imisebenzi yesiko, irhafu, okanye intlawulo yokungenisa okwenziweyo ngexesha lokuhambisa luxanduva lomthengi. Ezi ntlawulo ziyahluka ngokuxhomekeke kwilizwe eliya kulo kwaye zimiselwa ngabasemagunyeni basekhaya.
Ngokuthenga kwiwebhusayithi yethu, uyavuma ukuhlawula nayiphi na imisebenzi esebenzayo okanye irhafu enxulumene ne-oda yakho. Asinaxanduva lokulibaziseka okubangelwa kukucocwa kwesiko.
Umgaqo-nkqubo wePakeji yephakheji
Nje ukuba i-odolo yakho ifikile kwindawo echongiweyo yePickup okanye indawo yokuHanjiswa, nceda uqinisekise ukuqokelelwa ngokukhawuleza. Ukuba iphakheji ayithanga ngexesha elichongiweyo, siya kuthumela isikhumbuzo nge-imeyile okanye nge-SMS. Nangona kunjalo, ukuba iphakheji ayiqokelelwa ngaphakathi kwexesha elichaziweyo, kwaye nayiphi na ilahleko okanye umonakalo ovela ngenxa yoko, umthengi uya kuba noxanduva. Ngobubele kukhumbuza ukuba uqokelele iphakheji yakho ngokukhawuleza ukuphepha nayiphi na imiba enokubakho.
Qaphela: Njengoko imveliso yethu iwela phantsi kodidi olukhethekileyo, ibuyise kunye nokubuyiselwa kwemali ayamkelwa.
