Nhanganyaya
MUNA ZVESE - KUTAMBUDZIRA KWEMUKADZISI WEMAHARA, KUPEDZISIRA YEMAHARA YEMAHARA YEMAHARA YEMAHARA YAKADZIDZWA IZWI. Kuverengera kuchengetedzeka uye kushanda kwezvinhu zvipenyu, kunyanya munzvimbo yekuburembera kwekurapa kwesero, zvinofanirwa nematanho ekutora kuti uone uye kudzikisira DNA. Ichi chinyorwa chinopera zvakadzika mukukosha kwekuderedza DOOT muBiologics, nzira dzepasirese, nzira dzakajairika, uye njodzi dzakabatana. Isu tinosvitsa zvakare Jiangsu Hillgege uye mipiro yavo kumhando yemhando mukutonga kwekurapa kuburikidza nekwavoBluekit® chigadzirwa mutsara.
Kukosha kwekuderedza dna host DNA muBiologics
● Vachive nenjodzi dzimba
Rasara Zvimedu izvi zvinowanzozivikanwa seyekunze neiyo immune system, inotungamira kune inogona kuramba kurongeka kweiyo yekuzvisarudzira biologic.
● Regulatory Agency Zviyero
Maitiro ekuzvidzora pasi rese akaisa zviyero zvekutamba kuti ugonesera DOOT muBiologics. Iyi miyero inove nechokwadi chekuti zvigadzirwa zvekurapa zvakachengeteka kushandiswa, kudzivisa chero zvakashata mhedzisiro nekuda kwekuvapo kwematorwa eDNA.
● Kutyisidzira kuchengetedza kwehupenyu
Kuvapo kweDRODICADD DNA muBiologics kunomutsa zvakananga kutyisidzira kuchengetedza kwakachengeteka. Izvi zvinogona kusanganisira activation ye oncogene kana kutapurirana kwevamiriri vehutachiona, vachiita kuti zvive zvakakosha kuderedza DNA yakasara yekuenda kumazinga asingaonekwe.
Global Reglatory zviyero zveHard DNA dzidzo
● Nyika - yakatarwa miganhu
Nyika dzakasiyana dzakagadzira miganhu yakasarudzika yemazinga anogamuchirika emaDNA yeDNA muBiologics. Iyi miganhu inotsanangurwa zvichienderana neicho njodzi dzinogona kuitika uye kugona kwezviitiko zvazvino ruzivo.
● Stringen Donulatory zvinodiwa
Mitemo yekuzvidzora senge FDA, EMA, uye PMDA yakaisa mirayiridzo yakazara kuti ive nechokwadi chekuti biologics inosangana nemitemo yekuchengetedza. Kuomerera kune aya nhungamiro kwakakosha kuti ubvumirwe uye kushambadzira kwezvigadzirwa izvi.
● Pharmacpoeas 'nhungamiro
Pharmacopoeias across the globe, including the USP and EP, provide detailed procedures for the detection and quantification of residual host cell DNA. Iyi nhungamiro inoteverwa zvine mutsindo nevanogadzira kuti vave nechokwadi chekuchengetedza chigadzirwa uye kutevedzera.
Nzira dzakajairika dzeDhactual DNA rekuwanikwa
● Nhaurwa dzechikumbaridzo
Nzira dzechikumbaridzo dzinosanganisira kuiswa muganho wekuona kana chikumbaridzo cheiyo yakasara DNA. Kana iyo DNA chiyero mumuenzaniso unopfuura ichi chikumbaridzo, chinoratidza kuvapo kwenhamba isingagamuchiriki yeDNA REALIDUALD DNA.
● Maitiro e-hybridization
Maitiro ehurumende, akadai seasodzanyemba kudzima, anoshandiswa kuona chaiwo DNA kutevedzana mumuenzaniso. Idzi nzira dzakanyatsonaka uye dzinogona kuziva kunyange miniti huwandu hweDesitional DNA.
● Chaiye - Nguva Quicitative PCR
Chaizvoizvo - Nguva Quicitative PCR (QPCR) imwe yeiyo nzira dzinonakidza uye dzakashandiswa zvakanyanya uye dzinoshandiswa zvakanyanya kuti dzione. Inogona kudzora DNA ine hukakawanda, ichiita chishandiso chakakosha chekuchengetedza kuchengetedzeka kwezvinhu zvebhurogi.
Tsanangudzo uye njodzi dzefoni dzesero ramba
● Handei neDNA FLAGMENTS muBiologics
Host Cell Residhongwa DNA zvinoreva zvidimbu zveDNA kubva kumasero anoshandiswa kuburitsa biologics. Izvi zvidimbu zvinogona kusiyana muhukuru uye kutevedzana, zvichimisa huwandu hwakawanda hwengozi kune varwere.
● Njodzi dzinogona kunge dzichibva kuTumor - majini ane hukama
Residual DNA inogona kuve neyakateedzana ine chekuita neTumorigenesis. Kana izvi zvakatevedzana zvikabatanidzwa mumurwere genome, ivo vanogona kumisa Oncogene, vachitungamira mukuvandudzwa kwekenza.
● Virus - Yakanangana naJenta Zvinotadzisa
Resaraala DNA inogonawo kusanganisira kutevedzana kubva kune turuses inoshandiswa mukugadzira maitiro. Aya maitiro ehutachiona anokwanisa kuisa njodzi yehutachiona hwehutachiona kana kuisirwa, kuita kuti kuongororwa uye kubvisa kwakasimba.
Mienzaniso yenjodzi yakabvunzwa neDesidual DNA
● Utachiona hweHIV muFragment
Zvikwereti zvakasara zveDND Kuverengera kuti zvipenyu zvakasununguka kubva mukutsvagisa kwakadaro kwakakosha kuti uve nekuchengetedza murwere.
● Ras OncogeSe kuvapo
Kuvapo kweRas Oncogene muDzi Rakasara kunogona kutungamira kune isina kudzora cell chikamu uye cancer. Kuona uye kubvisa izvi kutevedzana kwakakosha kudzivirira zvido zvakadai.
● Mutsara - 1 kutevedzana kuisa mu chromosomes
Line - 1 kutevedzana ndeye Retrotransposons iyo inogona kubatanidza mu genome uye kukanganisa yakajairwa ne gene basa. Kuvapo kwavo muzvipenga kunokanganisa njodzi yakakosha uye inosimbisa kukosha kwekushanda kwakasara nguva dzekuchiva.
Kuipa kweDNAIDUALD DNA kuisirwa paGene Mabasa
● Activation of Oncogene
Reserial DNA kuisirwa kunogona kumisa Oncogene, kutungamira kune kusingadzoreki kuwanda kwemasero. Izvi zvinogona kuguma nekuvandudzwa kwemapundu uye mamwe mairinji.
● Kurudziro yeTumor Swastressor mainini
Resaraala DNA inogona kukanganisawo tumor suppressor majini, izvo zvakakosha zvekudzora kushandiswa kwesero. Kunyudza majini aya kunogona kubvisa macheki uye zviyero pane cell kuwedzera, kuchitungamira kukenza.
● Retrotrotranspospospospos
RetroNansposons, yakadai seTeck - 1, inogona kuteedzera uye kuiisa munzvimbo itsva mukati meiyo genome. Ichi chiitiko chinogona kukanganisa yakajairwa genne basa uye kubatsira kugadzikana genetic.
Microbial genomic dna uye immunogenicity
● CPG uye zvisinga zivikanwe zvakatevedzana
Microbial genomic DNA kazhinji ine zvisina kufanira cPG motifs, inozivikanwa nenzvimbo immune system sezvinoita njodzi zviratidzo. Aya motifs anogona kukonzera mhinduro yekushomeka, inotungamira mukuzvimba uye zvimwe zvinokanganisa.
● Njodzi dzakabatana neye mishonga yeprotein zvinodhaka
Recabhinant protein zvinodhaka, zvakagadzirwa uchishandisa microbial host, inogona kutakura nguva yakasara dhirowa DNA. Izvi zvinoisa njodzi yekukanganisa activation uye zvimwe zvinokanganisa, zvinoda kutaridzika kuona uye kubvisa maitiro.
● CPG motifs inokonzeresa kupindurwa kwemhinduro
Zviisungire CPG motifs mune yakasara microbial DNA inogona kumisikidza toll - SaRewptors pamasero emidziyo, zvichitungamira kumhinduro yekuzvisarudzira. Uku kugadzirwa kwekuita kunogona kukanganisa kuchengetedza uye kushanda kwe biologic kurapa.
Kufananidza kuongororwa kweTumorigenic uye hutachiona hwakatapukira
● Tumorigenic njodzi dzinopesana nenjodzi dzinotapukira
Hutsika hwakabvunzwa neDNADUALD DNA zvinogona kuve zvakazara zvakakamurwa kuita tumorigenic uye hutachiona hwakatapukira. Nepo njodzi yekuTumorigic inosanganisira iyo activation ye oncogence kana kukanganisa kweTumor Swoman gener majini, njodzi dzinotapukira dzinofanirwa nekutapurirana kwehutachiona hwehutachiona kana microbial kutevedzana.
● Kuedza kwemhuka kweTumorigenicity
Kuedza kwemhuka kunowanzoitwa kuti uongorore tumorigenic kugona kweDNADUAL DNA. Zvidzidzo izvi zvinosanganisira kuisanganisa zvigadzirwa zvebhasigic muzvipfuyo mumhuka uye kutarisisa kwekuvandudzwa kwevatama nekufamba kwenguva.
● Cellular Level Intantious Ongororo
Njodzi dzinotapukira dzinoongororwa kuburikidza neCellular kuyedza, uko zvigadzirwa zve biologic zvinoedzwa kuvapo kwekuvapo kwehutachiona kana microbial kutevedzana kunogona kukonzera kutapukirwa. Iyi miedzo inokosha yekuona kuchengetedzwa kwezvinhu zvipenyu.
Matanho ekudzivirira uye zviyero zvakasimba
● Kuwanikwa zviyero mu biologics
STRINGENT zviyero zvakatangwa zvekuonekwa kweDNA iyo yakasara DNA muBiologics. Iyi miyero inove nechokwadi chekuti zvigadzirwa chete zvemahara kubva kune zvinokuvadza DNASNOLES SEQUGLESS SEQUALES.
● Kuderedza njodzi dzine hutano
Kuderedza DNAZIDAL DNA muBiologics kwakakosha pakuderedza njodzi dzine hutano. Vagadziri vanoshandisa nzira dzakasiyana siyana dzekunatswa uye dzekuchenesa kuti uone kuti zvigadzirwa zvavo zvakachengeteka kushandiswa.
● Regulatory kutevedzera
Kuomerera kumitemo yekudzora yekudzora yeDNADUAL DNACtion inokosha yekubvumidzwa uye kushambadzira zvigadzirwa zvebhuroji. Kuteerana nemirairo iyi kunoita kuti zvigadzirwa zvinosangana nekuchengeteka kwakanyanya uye kugona kugona.
Nzira yemberi muHard DNA Ramba Ramba Resarame
● Kuvandudza nzira dzekuona
Iyo munda weiyo akasara DNA yekubvisirwa inogara ichishanduka, nenzira itsva nzira dziri kukudziridzwa kuti uvandudze kunzwa uye chokwadi. Izvi kufambira mberi kwakakosha kuti uve nechokwadi chekuchengetedza kwezvinhu zvebhurogi.
● Kuderedza njodzi dzakasara mumabhuku
Kuenderera mberi kwekutsvagisa zvinangwa zvekuvandudza maitiro matsva ekuzvinatsa uye maitiro ekugadzira kuti aderedze yakasara DNA muBiologics. Aya maitiro akakosha ekuderedza njodzi dzinoenderana ne biologic kurapwa.
● Kukurudzira zvinodhaka zvinodhaka
Kuvandudza nzira dzekuona uye kuderedza njodzi dzakasara dzinokosha kuti uwedzere kuwedzeredza mwero wekuchengetedza kwemishonga yemifananidzo. Aya kufambira mberi achave nechokwadi chekuti kurapa kwezvinhu zviperenji zvinoramba zvakachengeteka uye zvinoshanda kune varwere.
Jiangsu Hillgege uye Bluekit® mukana
Jiangsu Hillgege, Headabvture muSuZhou, China, neChipina Kugadzira muShenzhen uye Shanghai, uye nzvimbo iri kuvakwa muNorth Carolina, USA, iri pamberi pehunyanzvi hwekurapa. Yayo bluekit ® chigadzirwa tambo inosanganisira kits yekutsvaga zvasara zvasara zvasara zvasara zvasara uye zvinoshanda mukugadzirwa kwemishonga zvinodhaka, kuvimba nekumusoro - mhando dzekudzora maitiro. Hillgene's Platforms inotsigira kuvandudza mota - TCR - T, uye STEM Cell
Mhedziso
Kuona kuchengetedzwa kwezvinhu zvakasarudzika kunosanganisira kugona kwemaitiro uye kuderedzwa kweiyo yakasara host droc cell cell. Kuomerera kune Global Regulatory zviyero uye kushandisa nzira dzepamberi dzekutsvaga dzakasarudzika dzinodzora mukudzora njodzi dzakabvumidzwa neDNADUALD DNA. Jiangsu Hillgene, kuburikidza neyevhi yavo yeBluekit ®, inomiririra kuzvipira kune mhando yekudzora musero mukurapa, ichivira nzira yekuchengetedza uye zvakanyanya zvinoshanda biologic kurapa.
Kutumira Nguva: 2024 - 09 - 25 14:38:04
