Intangiriro
Mu bihe byose - Guhindura Umwanya wa biologique, kuba hari uwakiriye Apple yakiriye ADN itanga ikibazo gikomeye. Guharanira umutekano no gukora neza kwa biologique, cyane cyane mukarere ka Burgeoning of the orrimo selth, bisaba ingamba zikomeye zo kumenya no kugabanya ADN isigaye. Iyi ngingo isize cyane ku kamaro ko kugabanya ADN yakiriye muri biologique, ibipimo ngenderwaho ku isi, uburyo rusange bwo kumenya, hamwe n'ingaruka zijyanye. Turahangiza kandi juiagsu umusozi hamwe nintererano zabo muburyo bwiza bwo kuvura selile binyuze muriboBluekitUmurongo wibicuruzwa.
Akamaro ko Kugabanya ADN Yakiriye muri biologique
Guhindura Imyuka
APNAL ADN uhereye selile yo kwakira abashyitsi irashobora gukurura umuhanga mu barwayi kwakira ubuhanga bwa biologiya. Izi mpande zikunze kumenyekana nkabanyamahanga sisitemu yubudahangarwa, biganisha ku kwanga biologique yatanzwe.
Ibipimo ngengamikorere
Inzego zishinzwe kugenzura kwisi yose zashyizeho amahame ngenda rifatika kugirango agarukire ADN yakiriye muri biologique. Izihame zemeza ko ibicuruzwa bitanga umutekano kugirango bikoreshwe, kwirinda ingaruka mbi iyo ari yo yose kubera ko ADN y'ububanyi n'amahanga.
● Iterabwoba ryumutekano wubuzima
Kubaho kwa ADN ibisigazwa bya biologique byerekana iterabwoba ritaziguye kumutekano wihangana. Ibi birashobora kubamo ibikorwa bya Oncogtion cyangwa kwanduza abakozi bandura, bigatuma bigabanya gufungura ADN isigaye.
Ibipimo ngenderwaho byisi kuri DNA yakiriye
● Ingabo - Imipaka yihariye
Ibihugu bitandukanye byashizeho imipaka itandukanye kubice byemewe bya ADN isigaye muri biologique. Izi mipaka zigenwa zishingiye ku ngaruka zishobora kuba zifite ubushobozi bwo kumenya tekinoroji yubu.
● Ibisabwa
Imibiri ishinzwe kugenzura nka FDA, EMA, na PMDA yashyizeho umurongo ngenderwaho mu buryo bwuzuye kugira ngo ibihangange byubahiriza ibipimo ngenderwaho. Gukurikiza aya mabwiriza ningirakamaro kugirango byemerwe no kwamamaza ibi bicuruzwa.
Amabwiriza ya Pharmacopoeas
PharmacoPoEas hirya no hino ku isi, harimo USP na EP, itanga inzira zirambuye zo kumenya no kwinjiza ALCOR yakiriye ALC. Aya mabwiriza yakurikijwe cyane nabakora kugirango umutekano wibicuruzwa no kubahiriza.
Uburyo busanzwe bwo Gutahura ADN ya ADN
Uburyo bw'Uburinganire
Uburyo bubi burimo gushyiraho imipaka ntarengwa cyangwa imipaka ya ADN. Niba urwego rwa ADN rwicyitegererezo rurenze uru rugero, rwerekana ko hariho urwego rutemewe rwa ADN usigaye.
Tekinoroji ya hybridies
Ubuhanga bwa Hybridies, nko gukuramo amajyepfo, bikoreshwa mukumenya ADN yihariye kurugero. Ubu buryo burasobanutse kandi burashobora kumenya umubare munini wa ADN usigaye.
● nyayo - igihe ntarengwa PCR
Mubyukuri - Umwagihe wa PCR (QPCR) nimwe mubintu byoroshye kandi byakoreshejwe muburyo bukoreshwa muburyo butandukanye bwo kumenya ADN. Irashobora kubahiriza ADN ifite ubusobanuro bukabije, bikabigira igikoresho cyingenzi kugirango umenye umutekano wibikomokaho bya biologiya.
Ibisobanuro n'ingaruka za hor selile yakiriye ADN
● Ibice bya DNN muri biologique
Bakira selile ya ADN bivuga ibice bya ADN uhereye selile zikoreshwa mu gutanga ibinyabuzima. Ibi bice birashobora gutandukana mubunini no gukurikirana, kwifotoza gutandukana kwabarwayi.
● Ingaruka zishobora kubaho ziva mubibyimba - Bifitanye isano
ADN isigaye irashobora kubamo ibice bijyanye na Tumarigenesis. Niba ibyo bikurikiranye bihuza na genome yumurwayi, barashobora gukora kuri Oncourse, biganisha ku iterambere rya kanseri.
● Virusi - Ibyerekeye Gene
ADN isigaye irashobora kandi gushiramo ibice bya virusi ikoreshwa mubikorwa. Izi ngenderwaho za virusi zirashobora gutera ibyago byo kwandura virusi cyangwa reaction, bigatuma bamenya no gukuraho.
Ingero z'ingaruka ziterwa na ADN
Virusi itera SIDA mu gice cya ADN
Ibice bisigaye bya dna bikaba byanduye virusi itera sida birashobora guteza ibyago bikomeye byo kwandura. Kugenzura niba biologique bitarimo ibice nkibi ni ngombwa kugirango umutekano wihangare.
● Ras Oncogene ihari
Kubaho kwa Ras Oncog muri ADN ibisise bishobora kuganisha ku kugabana kanyuma kagenzurwa na kanseri. Gutahura no gukuraho izo ngeso ni ngombwa kugirango wirinde ibisubizo bibi.
● Umurongo - Inffionce 1 ikurikira muri chromosomes
Umurongo - 1 Urukurikirane ni retrotranspons zishobora kwishyira hamwe mubintu bya genome no guhungabanya imikorere isanzwe ya gene. Kubaho kwabo mumahanga bitera ibyago bikomeye kandi bishimangira ko hakenewe uburyo bwiza bwa ADN ya ADN.
Ingaruka zo Gusiba Dna Gushinga imikorere ya gene
● Gukora Oncogenes
Gusiba DNA ibisizwe birashobora gukora oncourse, biganisha ku gukwirakwiza katuhereguriwe. Ibi birashobora kuvamo iterambere ryibibyimba nibindi bibi.
Kubuza ibibyimba byo gushyushya genes
ADN isigaye irashobora kandi guhungabanya ingirabuzimafatizo zigera kuri kanseri, ni ngombwa mu kurwanya imikurire. Kubuza ingirabuzimafatizo bishobora gukuraho cheque no kuringaniza ku birori bya selile, biganisha kuri kanseri.
Ibikorwa retrotrannspon
Retrotransposspons, nkurwego - 1, irashobora gukoporora no kwinjizamo ahantu hashya muri genome. Iki gikorwa kirashobora guhungabanya imikorere isanzwe ya gene kandi ikagira uruhare mu guhungabana.
Microbial Genomic ADN na Immnunogenity
● CPG nibice bisesetse
Microbial ADN Asna isanzwe irimo motif ya CPG, izwi na sisitemu yumubiri nkibyange. Iyi motifs irashobora gutera umunyacyubahiro gusubiza, biganisha ku gutwika izindi ngaruka mbi.
INGARUKA ZIFATANYIJE N'IBIYOBYARA BY'UBUMENYE
Ibiyobyabwenge bya Protembinant, byakozwe ukoresheje mikorobe, birashobora gutwara afna isigaye. Ibi bitera ibyago byo gukora ubudahangarwa hamwe nizindi ngaruka mbi, bisaba kumenyana no gukuraho inzira.
● CPG Motifs ikurura imfuke
Bidasekwa CPG Motif muri mikorobile ya mikorobile irashobora gukora hejuru - Nkakirana nakirana ingirabuzimafatizo zubudahangarwa, biganisha ku gisubizo cyaka. Iyi mikorere yumubiri irashobora guteshuka umutekano nuburyo bwiza bwa treapies ya biologiya.
Isesengura rigereranya rya Timorigenic na Kubyara
● Ingaruka zo Tumarigenic n'ibibazo byanduye
Ingaruka ziterwa na ADN zisigaye zirashobora gushyirwa mu byiciro byinshi byingaruka za Tumarigenic kandi zandura. Mugihe ingaruka za Tumarigenic zirimo gukora kuri oncour cyangwa guhungabanya genes zishyushya javili, ingaruka ziterwa no kwandura zijyanye no kohereza virusi cyangwa mikorobe.
● Ubushakashatsi bwinyamanswa kugirango tumurikire
Ubushakashatsi bwinyamanswa bukunze gukorwa kugirango dusuzume ubushobozi bwa tumorigenic yo gufungura ADN. Ubu bushakashatsi burimo gutera imiyoboro ya biologiya mu nyamaswa no gukurikirana iterambere ryibibyimba mugihe.
● Urwego rwa selire
Ingaruka zanduza zisuzumwa binyuze mubushakashatsi bubi, aho ibicuruzwa bishingiye ku binyabuzima bigeragezwa kuba hari virusi cyangwa mikorobe ikurikirana ishoboye gutera kwandura. Ubu bushakashatsi ni ngombwa mu kubungabunga umutekano wa biologique.
Ingamba zo gukumira hamwe nubuziranenge
Ibipimo ngereranyo kuri biologique
Ibipimo ngenderwaho bifatika byashyizweho kugirango tumenye ADN usigaye muri biologique. Izi ngingo zemeza ko ibicuruzwa gusa bitarimo ADN yangiza ADN ikurikirana ku isoko.
● Kugabanya ingaruka zishobora kubaho
Kugabanya ADN isigaye muri biologique ni ngombwa mugugabanya ingaruka zishobora kubaho. Abakora bakoresha uburyo butandukanye bwo kwezwa no kumenya kugirango barebe ko ibicuruzwa byabo bifite umutekano kugirango bikoreshwe.
● Ubwumvikane
Gukurikiza amabwiriza yo kugenzura kugirango tumenye ADN ya ADN ni ngombwa kugirango tubyemeze no kwamamaza ibicuruzwa bya biologiya. Kubahiriza aya mabwiriza yemeza ko ibicuruzwa byujuje ubuziranenge busumba izindimutekano.
Icyerekezo kizaza muri host ubushakashatsi busigaye
Kunoza uburyo bwo kumenya
Umurima wibisigisigi usigaye kuri ADN uhora uhinduka, hamwe nuburyo bushya bwo gutezwa imbere kugirango utezimbere ibyiyumvo nibisobanuro. Iterambere ni ngombwa mu kubungabunga umutekano wibicuruzwa bya biologiya.
Kugabanya ingaruka zisigaye muri biologique
Ubushakashatsi bukomeje bugamije guteza imbere tekinike nshya yo kwezwa no gutunganya umusaruro kugirango dugabanye ADN isigaye muri biologique. Izi mbaraga ningirakamaro kugirango bigabanye ingaruka zijyanye na zoteri za biologiya.
Kuzamura ibipimo byumutekano wibiyobyabwenge
Kunoza uburyo bwo kumenya no kugabanya ingaruka zisigaye ni urufunguzo rwo kuzamura ibipimo byumutekano wibiyobyabwenge. Iterambere rizemeza ko imiyoboro y'ibinyabuzima ikomeza umutekano kandi igira ingaruka ku barwayi.
Jiangsu Hillgene hamwe ninyungu za Bluekit®
Jiangsu Hillgene, umuco i Suzhou, Ubushinwa, hamwe n'ibikoresho byo gukora muri Shenzhen na Shanghai, n'aho bakubiye mu majyaruguru ya Carolina, muri Amerika, ari ku isonga mu guhanga udushya muri selire. Umurongo wibicuruzwa byabo Bludikit urimo ibikoresho byo kumenya ibisigazwa bya biologiya n'imikorere mumivurungano yakagari, kubuza - Ibipimo ngenderwaho. Ihuriro rya Hillgene rishyigikira iterambere ryimodoka - t, TCR - T, na selile ya stem - Ibicuruzwa bishingiye kuri selile
Umwanzuro
Guharanira umutekano wa biologique birimo gutahura neza no kugabanya ingirabuzimafatizo basigaye. Gukurikiza ibipimo ngenderwaho ku isi no gukoresha uburyo bwateye imbere ni uburemere mu kugabanya ingaruka ziterwa na ADN. Jiangsu Hillgene, unyuze kumurongo wabo wubururu, agaragaza ko yiyemeje kugenzura ubuziranenge mubuvuzi bwa selire, ahagana inzira yo kuvuza ibinyabuzima kandi byiza bya biologiya.
Kohereza Igihe: 2024 - 09 - 25:38:04
