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Intangiriro Kuri Umuntu Il - 2 Ibikoresho bya Gutahura

Ibisobanuro n'akamaro

Interleukin - 2 (il - 2) ni cytokine yingenzi kuba umutunganya umubiri, ahanini yagize uruhare mubijyanye na selile yamaraso yera, ni ngombwa kugirango umurinzi wigihuruke. Umuntu Il - 2 Ibikoresho bya Gutahura nibikoresho byingenzi bikoreshwa mubushakashatsi hamwe nubuvuzi kugirango upime kwibanda kuri Il - 2 mubirori bitandukanye. Izi bice ni ngombwa kugirango ziteze imbere imyumvire yacu ku budahangarwa no guteza imbere uburyo bushya bwo kuvura, kuzamura imikorere ikoreshwa rya selire.

Akamaro ka Il - Gutahura bigurira mu mirima myinshi, harimo umufungo na Oncology, aho gusobanukirwa no guhindura ibisubizo byabigizemo uruhare bishobora gutera imbere mu kuvura. Nkuko inganda za biotech zihinduka, icyifuzo cyukuri, cyizewe, kandi cyiza cya 2 cyakiramo ni burgetoing, udushya dutwara udushya duturuka kubakora hamwe nibitanga kwisi yose.

● Ubwoko bwibinyabuzima Byakoreshejwe

Umuntu Il - 2 KitS irashobora gukoreshwa muburyo butandukanye bwibinyabuzima, harimo na serum, muri plasma, umuco ucogora, n'amaraso yose. Buri bwoko bwicyitegererezo gitanga ubushishozi nibibazo byihariye, bigatuma guhuza ibikoresho byo gutahura ikintu gikomeye mubikorwa byacyo. Kurugero, gusesengura umuco wa kagari karashobora gutanga amakuru arambuye kumusaruro wa Cytokine muri vitro, bifite agaciro cyane mubushakashatsi bwibanze bwumuhenga.

Uburyo bwa IL - Gutahura

Uruhare rwa antibodies na enzymes

Intangiriro yumuntu Il - Ibikoresho bya Gutahura 2 bishingiye ku gukoresha antibodies hamwe na enzymes kugirango bamenye neza kandi bagereranye il - molekile 2. Mubisanzwe, ibi bikoresho bikoresha sandwich Elisa (enzyme - yahujwe immnunsorbent. Muri ubu buhanga, il - 2 tekereza murugero rwafashwe hagati yibirindiro bibiri bya antibodies: antibod antibod ihambiriye hejuru kandi imenyekanisha antibod ihuza na enzyme. Enzyme yitwaye neza kugirango itange impinduka zibara rishobora gupimwa neza.

Ubu buryo bwo kumva kandi bwihariye biterwa cyane nubwiza bwa antibodies ikoreshwa, niyo mpamvu uhitamo uburenganzira bwa muntu Il - 2 Gutanga Ugutanga uburenganzira bwa muntu Abakora ibicuruzwa bizwi bagerageza antibodies bageragejwe kandi bemeza gutanga ibisubizo byizewe.

● Ubukana bwamabara na Il - 2 Umubare

Ibuye rikomeza kuvuza il - 2 mubyitegererezo ukoresheje ibikoresho byatanzwe nibara ryamabara ryakozwe na enzyme - Igisubizo. Ihinduka ryamabara riringaniye muburyo butaziguye kwibanda kuri Il - 2 murugero. Mugupima kwikuramo uburebure bwihariye, abashakashatsi barashobora kumenya neza Il - 2 Kwibandaho ukoresheje umurongo usanzwe ukomoka mubintu bizwi.

Gusaba Il - Gutahura

● t Amabwiriza yiterambere

Il - 2 ifite uruhare rwibanze mugutezimbere no gukwirakwiza selile ya T, bikenewe kugirango ubudahangarwa buhumure. Umuntu Il - 2 Ibikoresho bya Gutahura ningirakamaro mugukora iperereza ku gisubizo cya selile, bitanga ubushishozi mumabwiriza yubudahangarwa. Ibi bifite akamaro k'ubushakashatsi bwibanze gusa ahubwo no guteza imbere imiti yibasiye ubudahumam - Ingaruka zijyanye.

SHAKA Kanseri Imyumetherapiy na Concien

Uruhare rwa IL - 2 Mu guteza imbere ibisubizo bidahumurwa byakoreshejwe muri kanseri imbinorapi, cyane cyane mu kuvura bugamije kuzamura ubushobozi bwa sisitemu yumubiri bwo kurwanya ibibyimba. Umuntu Il - Ibikoresho bya Gutahura nibyingenzi muriyi miterere, bituma gukurikirana ibikorwa byakazi byubudahangarwa nubuvuzi bworoshya, bityo byorohereza uburyo bwo kuvura protocole.

Incamake ya Il - 2 Ubwoko bwa Kit

● Elispot Kits: Kumva no gutunganya

Elispot (Enzyme - Ihujwe Immonaspot) isuzuma rizwi cyane kubyo birumvikana, bishoboye gutahura Cytokine kuri buri rwego urwego rumwe. Umuntu Il - 2 Elispot Kits ni ingirakamaro cyane mukumenya Il - 2 Ingirabuzimafatizo 2 ziba mu baturage, zitanga isesengura ryinshi kandi ryujuje ubuziranenge. Ubu busobanuro bukomeye ni ntagereranywa mubushakashatsi bwumuhenga, cyane cyane mugihe ubonye amafaranga make - Urwego Cytokine ibisubizo muburyo butandukanye.

● Elisa Kits: Ubuntu bwo gusuzuma tekinike

Ibikoresho bya Elisa ni imirimo ya Ctokine, tanga uburyo bukomeye kandi butazirikana bwo guhuza Il - 2 mubwoko bwinshi bwicyitegererezo. Umuntu Il - 2 Elisa Ibikoresho byizere byo kwizerwa no koroshya imikoreshereze, bikaba bituma iba iperereza ryubumuga bwo gukora, inkingo, nindwara Pathogene.

Elispot Kit Ibiranga ninyungu

Microplate - Assay ashingiye

Imiterere ya microplate ya Elispot ifasha yemerera hejuru - Kwiyandikisha, bikaba byiza mubushakashatsi bunini. Ubushobozi bwo kugerageza ingero nyinshi icyarimwe kuzamura imico mibare kandi bigabanya imiterere itandukanye, bitanga amakuru yizewe muburyo bwinshi bwo kugerageza.

● Ubushishozi bwo hejuru kubisubizo bike

Imwe mu bintu biranga Abanyalispot ibikoresho bya Elispot nubushobozi bwabo bwo kumenya ibisubizo byikigo, bikomeye mubushakashatsi bwumupfumu aho bike cyane - ibintu byinshi bishobora kugira ingaruka zikomeye mubinyabuzima. Ibi bitekerezo bituma Elispot igikoresho cyiza cyubushakashatsi bwikiruhuko niterambere ryumuhenga.

Ububiko bwa Elisa bwasobanuye

● Tekinike ya Sandwich Elisa

Sandwich Elisa nuburyo bwiganjemo uburyo bukoreshwa muri LILL IL - 2 Ibikoresho bya leta bitewe nuburyo bwihariye no kwiyumvisha. Ubu buhanga burimo guhuza intego ya Il - 2 Kuri Antibody yafashwe, hakurikiraho kumenya unyuze kuri Enzyme ya kabiri, ihujwe na antibody

Gupima Il - 2 muri Plasma na ndenda

Umuntu Il - 2 Elisa Ibikoresho byinshi bikoreshwa cyane mugupima Sitokine urwego rwa Clasma na selile umuco. Ubushobozi bwo gusesengura Il - 2 Kwibanda kuri aya mazi ni ngombwa kugirango dusobanukirwe na sisitemu ya sisitemu kandi bidafite ishingiro ryibisubizo byibandaho byibanda ku ndwara zashishikarizwa no gutabara.

Amabara ya Elisa Kumenyekanisha Ibikoresho Bit

Prote - na - Inzira

UBURYO BWO GUKORA AMAFARANGA YAMAFARANGA YIFATANYIJE INTAMBWE RITANGIRA HAMWE N'UBURYO BWO GUTEGURA, BIKURIKIRA NAMWE N'AMAHARE YAFATANYIJE. Nyuma yo koza byinshi kugirango ukureho ibintu bifatika, imenyekanisha antibonges yongeyeho. Intambwe yanyuma ikubiyemo inyongera yinyoni igaragara hamwe na enzyme kugirango itange ibara risoze, ritanga amakuru yumubare kuri il - urwego 2.

● Umubare mu muco w'akagari

Kugereranya Il - 2 Mumuco gakondo umuco gatanga ubushishozi kumusaruro wa Cytokine mubihe bitandukanye byubushakashatsi. Ibi nibyingenzi mu nyigisho Ibisubizo bidahumanye, aho kugena urwego rwa Cytokine rushobora gufasha mugusobanukirwa inzira ya selile ningaruka zibiyobyabwenge.

Akamaro k'Ukuri IL - 2 gupima

Ubushakashatsi hamwe nubuvuzi

Byukuri Il - 2 Igipimo ni ishingiro ryubushakashatsi nubuvuzi. Mu bushakashatsi, butuma habaho kuranga ibintu bidasobanutse, kumenyesha iterambere ry imyumufungo ninkingo. Calnic, IL - Urwego Rushobora kuba muri Biomarkers ku ndwara cyangwa Igisubizo cya TheRapeutic, gufasha mu micungire y'abarwayi no gukunda imiti.

● Ingaruka kuri Cytokine Kwiga no kuvura

Ubushobozi bwo gupima Il - 2 neza hamwe nibisobanuro byimbitse kubijyanye na Cytokine kwiga no kuvura. Yorohereza gusobanukirwa byimbitse ku miyoboro ya cytokine n'imirwano yabo mu buzima n'indwara, amaherezo igashyiraho iterambere ry'iterambere rya cytokine ryagenewe Cyito rishobora guhindura imikorere idahangahanga.

Ibibazo muri Il - Gutahura

● Tyumvitivite hamwe nibibazo byihariye

Imwe mu mbogamizi z'ibanze muri IL - Gutahura ni uguhabwa ibitekerezo bihagije kandi byihariye. Gutandukana muri antibody imikorere birashobora gutuma bidahuye, bishimangira akamaro ko guhitamo abantu bizewe byizewe. 2

● Biratandukanye muri sample

Indi mbogamizi zikomeye ni itandukaniro ryatangijwe mugihe cyicyitegererezo no kwitegura, bishobora kugira ingaruka kubisobanuro nyabyo no kubyara. Porotokole n'amahugurwa ni ngombwa mu kugabanya ibyo bibazo, menyesha ko amakuru yabonetse muri LILL IL - 2 Ibikoresho byo gutahura kandi byizewe.

Ibizaza muri IL - 2 Gutahura Ibikoresho

Iterambere ryikoranabuhanga

Kazoza ka LIL - Ibikoresho byo gutahura 2 bitanga ikizere, hamwe niterambere ryikoranabuhanga rihuza ibyiyumvo byayo, umwihariko, noroshye gukoresha. Udushya nka ConstayxsxsxSx

● Porogaramu yagutse kandi udushya

Mugihe dusobanukiwe na Il - 2 Ibinyabuzima byaguka, niko gusaba kuri Il - Ibikoresho 2 byo gutahura. Ingamba zo Kwerekana Ingamba zigamije Il - Imihanda 2 iri kuri horizon, ishobora guhindura amahitamo yo kuvura indwara za automune, kanseri, ndetse no hanze yacyo. Gukomeza guhanga kubuntu kubuntu

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Bluekit by Jiagsu Hillgene, icyicaro cya Suzhou, ni izina ryambere mubuvuzi bwa selire. Hamwe na leta yacyo - ya - - Ubuhanzi GMP ibigo na R & D, byashyizeho imbuga zo gukora Ubushinwa kandi ikagura kwisi yose. Hillgene kabuhariwe mu rubuga rwo guteza imbere intoki za Acic na QC, gushyigikira iterambere ry'imodoka - T, TCR - T, na selile ya stem - Ibicuruzwa bishingiye ku giti cye. Yiyemeje kwihutisha ibicuruzwa bitera imivurure,Bluekitni kimwe no kugenzura ubuziranenge mumikorere yibiyobyabwenge. Inshingano zabo zikomeje gutera imbere mubicuruzwa bitesha umutwe, kugirira akamaro abarwayi ku isi.